| Autor: |
Feigenbaum PA, Medsger TA Jr, Kraines RG, Fries JF |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of rheumatology [J Rheumatol] 1982 May-Jun; Vol. 9 (3), pp. 408-14. |
| Abstrakt: |
To determine the clinical reliability of certain immunologic tests, serum complement (C3), DNA binding (DNAB), and fluorescent antinuclear antibody (FANA) were measured blindly at 2 university immunology laboratories on duplicate serum samples from 667 patients with connective tissue diseases. Twenty-seven percent of patients were differently classified as normal or abnormal for C3 by the 2 laboratories. The mean of paired differences was 25 mg% and large variability remained even after adjustment. Repeat assays on a random subset of 91 sera showed persistent variability. Fifteen percent of patients were differently classified by their DNAB results in 11% by FANA tests. Considering this variability, these "objective" laboratory tests alone are not sufficiently reliable for accurately defining diseases or disease activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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