| Autor: |
Bast EJ, Van Camp B, Boom SE, Jaspers FC, Ballieux RE |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and experimental immunology [Clin Exp Immunol] 1981 May; Vol. 44 (2), pp. 375-82. |
| Abstrakt: |
Malignant monoclonal gammopathy (MMG) cannot easily be distinguished from the benign (BMG) form in a number of cases. Using two different anti-J chain reagents it could be shown in the present study that in MMG, J chain is present in most of the IgG-containing plasma cells in the bone marrow. In BMG, the frequency of J chain-containing IgG plasma cells is low and not different from that obtained in healthy individuals. Essentially similar findings regarding idiotype were obtained, using anti-idiotype conjugates, specific for the patients' monoclonal immunoglobulins. In one patient malignancy was indicated by the presence of a high percentage of J chain-containing IgG plasma cells in the bone marrow, prior to clinical expression of multiple myeloma. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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