| Autor: |
Heston WD, Lazan DW, Fair WR |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 1981 Feb; Vol. 11 (4), pp. 323-30. |
| DOI: |
10.1016/0304-3835(81)90098-7 |
| Abstrakt: |
In in vitro studies with the Copenhagen rat prostate-derived tumor cell lines, the activity of ornithine decarboxylase (ODC) of these lines were as sensitive to inhibition by alpha-difluoromethylornithine (alpha-DFMO) as normal prostatic tissue. The in vitro growth of the tumor in calf serum was inhibited by ODC inhibitors alpha-methylornithine and alpha-difluoromethylornithine. This inhibition was partially reversed by the diamine oxidase inhibitor aminoguanidine. Further, alpha-DFMO was not inhibitory to the growth of these cells in sera which lacked diamine oxidase activity, but was inhibitory when diamine oxidase was added. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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