| Autor: |
Brundidge SP, Gaeta FC, Hook DJ, Sapino C Jr, Elander RP, Morin RB |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 1980 Nov; Vol. 33 (11), pp. 1348-51. |
| DOI: |
10.7164/antibiotics.33.1348 |
| Abstrakt: |
Analysis of a 13C NMR spectrum of a concentrated broth from Penicillium chrysogenum fermentation revealed the presence of penicillin V and 6-oxo-piperidine-2-carboxylic acid(1) as the principal constituents. The latter lactam, identical to an authentic sample prepared by the cyclization of alpha-aminoadipic acid was present to the extent of 28 mol% of penicillin V. The lactam isolated form the broth was nearly racemic, having a slight excess of the L-isomer. This isolation provides further evidence regarding the biosynthetic precursors of the hydrophobic penicillins. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
