| Abstrakt: |
Pyrazidol (1,10-trimethylene-3-methyl-1,2,3,4-tetrahydropyrazino(1,2-a)indole hydrochloride) in low concentrations (0.005 mM) completely blocks the deamination of serotonin, partially that of tyramine, and does not virtually affect the deamination of 2-phenylethylamine by the mitochondria of intestinal cells. There is evidence for the presence of types A and B monoamine oxidases in the rat intestine. Pyrazidol appears to be a selective inhibitor of type A monoamine oxidase of the rat intestine. |
