| Autor: |
Powers ER, Bannerman KS, Stone J, Reison DS, Escala EL, Kalischer A, Weiss MB, Sciacca RR, Cannon PJ |
| Jazyk: |
angličtina |
| Zdroj: |
American heart journal [Am Heart J] 1982 Nov; Vol. 104 (5 Pt 2), pp. 1203-10. |
| DOI: |
10.1016/0002-8703(82)90052-7 |
| Abstrakt: |
The effects of captopril (CPT), an oral angiotensin-converting enzyme (ACE) inhibitor, on systemic failure (CHF). In 15 patients, CPT decreased mean arterial pressure from 75 +/- 3 to 60 +/- 3 mm Hg associated with a 16% increase in cardiac output, a 24% reduction in systemic vascular resistance, and a 36% decrease in pulmonary capillary wedge pressure (all p less than 0.01). Despite the improved cardiac output, renal blood flow, creatinine clearance, and sodium excretion did not rise during the first 2 days of CPT therapy. In eight patients, coronary sinus blood flow diminished from 98 +/- 11 to 82 +/- 9 ml/min (p less than 0.01) following drug administration in association with a fall in arterial pressure and heart rate but no change in coronary sinus oxygen inhibitor failed to improve renal hemodynamics. In addition, initial CPT administration produced a decrease in coronary blood flow that was related to a decrease in myocardial oxygen requirements. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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