| Autor: |
Laschinger C, Gauthier D, Valet JP, Naylor DH |
| Jazyk: |
angličtina |
| Zdroj: |
Vox sanguinis [Vox Sang] 1984; Vol. 47 (1), pp. 60-7. |
| DOI: |
10.1111/j.1423-0410.1984.tb01562.x |
| Abstrakt: |
Monitoring of donors with selective IgA deficiency, i.e., with less than 0.5 mg IgA/l, led to the observation that serum IgA levels wer not constant. Small but significant fluctuations in IgA levels were noted (coefficient of variance: 143%) which were greater than the variability inherent in the testing methodology (coefficient of variance: 10%). These fluctuations created difficulties in terms of defining IgA-deficient blood products and had implications with respect to the mechanisms involved in IgA deficiency. With respect to supplying IgA-deficient blood products, in our experience a cutoff level of 0.5 mg/l should be the maximum permissible IgA concentration in order to ensure that no adverse reactions occur in individuals with class-specific anti-IgA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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