| Autor: |
Erin AN, Spirin MM, Tabidze LV, Kagan VE |
| Jazyk: |
angličtina |
| Zdroj: |
Biochimica et biophysica acta [Biochim Biophys Acta] 1984 Jul 11; Vol. 774 (1), pp. 96-102. |
| DOI: |
10.1016/0005-2736(84)90279-7 |
| Abstrakt: |
The formation of alpha-tocopherol complexes with saturated and unsaturated fatty acids in ethanol has been demonstrated. The values of equilibrium constants for alpha-tocopherol interactions with fatty acids have been determined. These values do not depend in practice on the number of carbon atoms in saturated fatty acid molecules (from 7:0 to 24:0) and are equal to about 40-50 M-1. For unsaturated fatty acids the values of equilibrium constants are increased exponentially with an increase in the number of double bonds in the fatty acid molecule (1.25 X 10(4) M-1 for arachidonic acid). alpha-Tocopherol can form complexes with free fatty acids incorporated into phosphatidylcholine liposomes or into skeletal muscle sarcoplasmic reticulum membranes. The formation of alpha-tocopherol complexes with free fatty acids is regarded as a molecular mechanism of membrane stabilization by vitamin E against the damaging action of free fatty acids. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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