| Abstrakt: |
Experiments on 234 guinea-pigs were made to study the effects of 3 shock-inducing agents (acute hemorrhage, graded chest injury, Salmonella endotoxin). Application of histological methods, electron microscopy, electron histochemistry with the use of rutenium red and Pattle 's method for determining the stability of pulmonary vesicles disclosed that the typical reaction seen within the first 6 hours was the spasm of bronchioles and venules, followed by the development of bilateral small-focal contractile atelectases and microcirculatory disorders in the form of the sludge syndrome, leukostasis, accumulation of megakaryocytes, DVS , and dystrophy of the capillary endothelium. Following 12-24 hours structural changes in the surfactant system supervened: the loss of lamillar bodies by large alveolocytes, disorganization of the surfactant film, a critical fall of the Pattle stability. Intraalveolar edema was recorded at the ultrastructural level after 6-12 hours and at the histological level after 24 hours. The degree and time of the development of the changes depended on the type of a shock-inducing agent. |
