Synthesis and antiallergic activity of some mono- and disubstituted xanthone-2-carboxylic acids.

Autor: Pfister JR, Ferraresi RW, Harrison IT, Rooks WH, Fried JH
Jazyk: angličtina
Zdroj: Journal of medicinal chemistry [J Med Chem] 1978 Jul; Vol. 21 (7), pp. 669-72.
DOI: 10.1021/jm00205a014
Abstrakt: A series of xanthone-2-carboxylic acids, substituted mainly with electron-withdrawing groups, has been synthesized and assayed for antiallergic activity, using the passive cutaneous anaphylaxis (PCA) reaction in the rat. The effect of substituent type and substitution pattern on PCA neutralizing capacity is presented.
Databáze: MEDLINE