Synthesis and antiinflammatory activity of trisubstituted pyrimidines and triazines.
Autor: | Bennett GB, Mason RB, Alden LJ, Roach JB Jr |
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Jazyk: | angličtina |
Zdroj: | Journal of medicinal chemistry [J Med Chem] 1978 Jul; Vol. 21 (7), pp. 623-8. |
DOI: | 10.1021/jm00205a006 |
Abstrakt: | A series of mono-, bi-, and tricyclic pyrimidines and as-triazines was prepared and their antiinflammatory activity measured against carrageenan-induced edema in the rat. The more active analogues (ED50), including 4-pyri-dylpyrimidines 4a (38), 4b (47), and 4g (49) and 2-hydroxypyrimidine 8r (43), were then tested against adjuvant-induced edema in the rat. None was active in the adjuvant arthritis model. |
Databáze: | MEDLINE |
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