Effect of cyclophosphamide on the immune responsiveness of jirds infected with Brugia pahangi.
| Autor: | Katz SP, Lammie PJ |
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| Jazyk: | angličtina |
| Zdroj: | Infection and immunity [Infect Immun] 1984 Feb; Vol. 43 (2), pp. 753-5. |
| DOI: | 10.1128/iai.43.2.753-755.1984 |
| Abstrakt: | The in vitro immune responsiveness of lymphocytes from Brugia pahangi-infected jirds was examined after serial administration of cyclophosphamide (20 mg/kg). Cyclophosphamide had no effect on parasite burdens, anti-B. pahangi antibody titers, or suppressed spleen cell reactivity to B. pahangi antigens. Cyclophosphamide restored cellular responsiveness to the mitogens phytohemagglutinin, concanavalin A, and pokeweed mitogen. |
| Databáze: | MEDLINE |
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