Relationship between cortisol and cholesterol in men with coronary artery disease and type A behavior.

Autor: Schwertner HA, Troxler RG, Uhl GS, Jackson WG
Jazyk: angličtina
Zdroj: Arteriosclerosis (Dallas, Tex.) [Arteriosclerosis] 1984 Jan-Feb; Vol. 4 (1), pp. 59-64.
DOI: 10.1161/01.atv.4.1.59
Abstrakt: To further understand the hormonal mechanisms linking behavior pattern and coronary artery disease (CAD), we investigated the relationship between 0930-hour plasma cortisol and cholesterol in relatively young males who had undergone coronary angiography and in a subgroup of individuals who had undergone the structured interview for classification of behavior pattern. A statistically significant association (p less than 0.05) was found between cortisol and cholesterol for individuals who had either minimal CAD (20% to 49% narrowing) or significant CAD (greater than or equal to 50% narrowing), but not for subjects without CAD. An association between cortisol and cholesterol was also found to be significant for the subgroup of individuals with Type A-1 behavior pattern, but not for those with Type A-2, X, or B behavior patterns. The findings suggest that hormonal mechanisms involving cortisol and cholesterol metabolism may be operative in individuals with CAD as well as in individuals with Type A-1 behavior.
Databáze: MEDLINE