[The role of thyroglobulin carbohydrates in its hormone-liberating function. Proteolysis of deglycosylated thyroglobulin].

Autor: Vikha GV, Kaverzneva ED, Alimbabaeva NT, Babaev TA
Jazyk: ruština
Zdroj: Bioorganicheskaia khimiia [Bioorg Khim] 1983 Aug; Vol. 9 (8), pp. 1142-4.
Abstrakt: The proteolysis of thyroglobulin was performed after partial cleavage of its carbohydrate moiety. It was demonstrated that enzymatic removal of some thyroglobulin sialic acids results in increasing its resistance to proteolysis. Apparently, sialic acids are essential for maintaining an optimal thyroglobulin conformation for the action of proteases at hormonal biosynthesis from the reserve form.
Databáze: MEDLINE