| Autor: |
Hoover RL, Briggs RT, Karnovsky MJ |
| Jazyk: |
angličtina |
| Zdroj: |
Cell [Cell] 1978 Jun; Vol. 14 (2), pp. 423-8. |
| DOI: |
10.1016/0092-8674(78)90127-7 |
| Abstrakt: |
The results of this investigation indicate an adhesive specificity between PMN and cultured endothelial cells. This was monitored by the mono-layer collection assay and by direct cell counts using the scanning electron microscope. Both techniques showed that significantly more PMN attached to endothelial cells than to a variety of other cell types. The interaction can be modulated by divalent cations and neuraminidase, implying a role for surface charge. In the presence of chemotactic agents, the number of PMN adhering to endothelial cells increases. This system presents a good model for studying the process of PMN margination which occurs in vivo during the acute inflammatory response. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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