| Autor: |
Norbury HM, Franklin RA, Marrott PK, Warrington SJ |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of clinical pharmacology [Eur J Clin Pharmacol] 1983; Vol. 25 (2), pp. 243-6. |
| DOI: |
10.1007/BF00543798 |
| Abstrakt: |
The pharmacokinetics of indoramin (Baratol) have been studied in five male and five female healthy, middle-aged volunteers after intravenous administration (0.14 mg/kg). Elimination occurred in an apparently biexponential fashion with a mean elimination half-life of 4.0 h (+/- 0.25 SEM). The mean plasma clearance was 19.9 ml/min/kg (+/- 1.32 SEM) and the mean volume of distribution 7.4 l/kg (+/- 0.81 SEM). There were no significant differences in these parameters between male and female volunteers. Protein binding of indoramin ranged from 85.6% at 81 ng/ml to 72.2% at 129 micrograms/ml. Two classes of binding site were evident, with affinity constants of 6.85 X 10(4)M -1 and 4.30 X 10(3)M -1. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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