| Abstrakt: |
The therapeutic effect of the non-cardioselective beta-blocker corgard (nadolol) was examined in 40 patients with stage II essential hypertension. In 22 of those, central, intracardiac and regional hemodynamics were measured echocardiographically and rheographically after 2 and 4 weeks of treatment. Blood pressure dropped significantly by days 8-13 of treatment, as a result of cardiac index reduction mainly due to decreased heart rate. At the same time, a moderate yet significant rise in total peripheral vascular resistance was noted. Intramyocardial tension decreased, as did the thickness of the left-ventricular posterior wall and interventricular septum, which caused a significant (6.74%) reduction in myocardial weight. |
