| Autor: |
Luscombe M, Poulding JM, Amer B, Clamp JR, Hartog M, Shelley JH, Tribe CR |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of experimental pathology [Br J Exp Pathol] 1983 Aug; Vol. 64 (4), pp. 462-5. |
| Abstrakt: |
Diabetes was induced in male Wistar rats by a single i.v. injection of streptozotocin (40 mg/kg). Animals were treated with bromhexine at 2 dose levels (2.5 mg/kg/day and 25 mg/kg/day) for 13 months thereafter and compared to non-diabetic controls and untreated diabetic animals. Renal pathology showed a significant increase in glomerular volume and basement membrane thickening in untreated diabetic animals. The higher dose bromhexine treated diabetic animals showed a significant decrease in glomerular volume as compared with diabetic animals not given bromhexine. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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