Irradiation-hyperthermia in canine hemangiopericytomas: large-animal model for therapeutic response.

Autor: Richardson RC, Anderson VL, Voorhees WD 3rd, Blevins WE, Inskeep TK, Janas W, Shupe RE, Babbs CF
Jazyk: angličtina
Zdroj: Journal of the National Cancer Institute [J Natl Cancer Inst] 1984 Nov; Vol. 73 (5), pp. 1187-94.
Abstrakt: Results of irradiation-hyperthermia treatment in 11 dogs with naturally occurring hemangiopericytoma were reported. Similarities of canine and human hemangiopericytomas were described. Orthovoltage X-irradiation followed by microwave-induced hyperthermia resulted in a 91% objective response rate. A statistical procedure was given to evaluate quantitatively the clinical behavior of locally invasive, nonmetastatic tumors in dogs that were undergoing therapy for control of local disease. The procedure used a small sample size and demonstrated distribution of the data on a scaled response as well as transformation of the data through classical parametric and nonparametric statistical methods. These statistical methods set confidence limits on the population mean and placed tolerance limits on a population percentage. Application of the statistical methods to human and animal clinical trials was apparent.
Databáze: MEDLINE