Influence of environmental conditions on exocrine pancreatic response to intravenous injection of ethanol or 2-deoxyglucose in the dog.

Autor: Sarles H, Johnson C, Devaux MA, Noel-Jorand MC, Diaz GR, Schmidt D
Jazyk: angličtina
Zdroj: Digestive diseases and sciences [Dig Dis Sci] 1984 Jan; Vol. 29 (1), pp. 19-25.
DOI: 10.1007/BF01296857
Abstrakt: When dogs have free access to the outside, an intravenous injection of ethanol depresses secretin-stimulated exocrine pancreatic secretion by a vagally mediated mechanism. This was shown in two separate series of six and seven dogs each. When dogs were kept in air-conditioned windowless kennels, the response to a meal was unchanged but the response to ethanol was reversed to stimulation. In four dogs, ethanol 1 g/kg was given during a secretin infusion. Three months after changing from open to closed kennels the inhibition (-86% for protein output) was still present, but after 6 months ethanol produced a stimulation (+62%) of pancreatic secretion. This increase was abolished, but not reversed, by keeping the animals outside during the day for four weeks, whereas after three months there was a partial restoration of the inhibitory effect (-39%). In contrast, changing from an open to a closed kennel changed the initial response to 2-deoxy-D-glucose (2-DG), 100 mg/kg, from stimulation to inhibition. These results suggest that environmental conditions affect the cranial regulation of pancreatic secretion.
Databáze: MEDLINE