Autor: |
Lynn MD, Shapiro B, Sisson JC, Swanson DP, Mangner TJ, Wieland DM, Meyers LJ, Glowniak JV, Beierwaltes WH |
Jazyk: |
angličtina |
Zdroj: |
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 1984 Apr; Vol. 25 (4), pp. 436-40. |
Abstrakt: |
The radiopharmaceutical m-[131I]iodobenzylguanidine (I-131 MIBG), which is readily taken up by adrenergic vesicles, produces scintigraphic images of pheochromocytomas in man but rarely visualizes normal adrenal glands. Iodine-123 has many potential advantages over I-131 as a radiolabel for MIBG, including shorter half-life, freedom from beta emissions, and increased gamma-camera efficiency. In this study, diagnostic doses of MIBG labeled with I-131 and I-123, with nearly equivalent radiation dosimetry, were compared as imaging agents in eight patients with known or suspected pheochromocytoma. Images of superior quality were obtained with I-123 MIBG, and lesions not visualized using I-131 MIBG were portrayed. In addition, the normal adrenal medullae were visualized on the I-123 MIBG scintigrams in six out of eight patients. |
Databáze: |
MEDLINE |
Externí odkaz: |
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