| Autor: |
Hanig JP, Yoder PD, Krop S |
| Jazyk: |
angličtina |
| Zdroj: |
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 1984 Mar; Vol. 22 (3), pp. 185-9. |
| DOI: |
10.1016/0278-6915(84)90125-x |
| Abstrakt: |
The antioxidants butylated hydroxytoluene (BHT) and ethoxyquin protected rats against intoxication and mortality normally produced by hexachlorophene (HCP, 100 mg/kg). BHT also prevented the elevation of cerebrospinal fluid pressure, a central nervous system effect of HCP poisoning. In addition, both phenobarbital and SKF-525A protected against HCP poisoning, with the barbiturate also offering significant protection against triethyltin. L-Ascorbic acid, vitamin E, N,N-diphenyl-p-phenylenediamine and reduced and oxidized glutathione over a range of doses were ineffective in preventing HCP lethality. The protective effect of phenobarbital against HCP and triethyltin intoxication further supports existing evidence of a common or similar mechanism of toxic action for these two structurally dissimilar compounds. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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