| Autor: |
Shengeliia MG, Gachava MM, Tsartsidze MA, Lomsadze BA |
| Jazyk: |
ruština |
| Zdroj: |
Nauchnye doklady vysshei shkoly. Biologicheskie nauki [Nauchnye Doki Vyss Shkoly Biol Nauki] 1984 (11), pp. 34-6. |
| Abstrakt: |
DNA interaction with cholesterol at various lipid concentrations has been investigated by the fluorescent probes method. It has been shown that the intensity of acridine orange fluorescence in the DNA-cholesterol complex decreases at 24 micrograms/ml cholesterol and at 45 micrograms/ml it increases. The number of binding sites and the degree of polarization of fluorescence change simultaneously. Binary mechanism of cholesterol binding with DNA has been suggested: surface binding takes place at low concentrations, intercalation--at high lipid concentrations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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