| Autor: |
Kumor KM, McDonald JM, Lietman PS |
| Jazyk: |
angličtina |
| Zdroj: |
Developmental pharmacology and therapeutics [Dev Pharmacol Ther] 1984; Vol. 7 (6), pp. 368-76. |
| DOI: |
10.1159/000457188 |
| Abstrakt: |
17 children with serious infections were treated for an average period of 9.5 days with 420 mg/m2/dose of amikacin every 8 h. The nephrotoxicity and ototoxicity of this 'high-dose' regimen was studied. None of the children had evidence of nephrotoxicity. Of 9 children who could be clearly evaluated, 1 child experienced a delayed transient auditory dysfunction. 1 child experienced delayed serious deafness, but was receiving other ototoxic drugs. Despite the fact that the doses averaged 54.1 mg/kg/day, 5 children in our series had peak concentrations lower than that recommended for adults with serious infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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