| Autor: |
Spence CD, Coghlan JP, Denton DA, Gomez-Sanchez CE, Mills EH, Nelson MA, Whitworth JA, Scoggins BA |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and experimental hypertension. Part A, Theory and practice [Clin Exp Hypertens A] 1984; Vol. 6 (9), pp. 1591-600. |
| DOI: |
10.3109/10641968409044071 |
| Abstrakt: |
The present study examines the blood pressure and metabolic effects of 5 day infusions of 19-nor-deoxycorticosterone (19-nor-DOC) and 19- nor-progesterone (19-nor-PROG) in the intact conscious sheep. Both these steroids raise blood pressure in the rat. 19-nor-DOC (5 mg/d) produced a significant increase in mean arterial pressure (MAP) of 17 mmHg on day 5 (p less than 0.001), associated with 'mineralocorticoid' effects hypokalaemia, hypernatraemia and an initial urinary sodium retention. In contrast 19-nor-PROG (5 mg/d and 50 mg/d) had no effect on MAP and displayed no 'mineralocorticoid' activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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