2-Pyrrolidinone and succinimide endogenously present in several mammalian species.

Autor: Bandle EF, Wendt G, Ranalder UB, Trautmann KH
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 1984 Nov 26; Vol. 35 (22), pp. 2205-12.
DOI: 10.1016/0024-3205(84)90461-2
Abstrakt: 2-Pyrrolidinone and succinimide were identified in blood plasma of man, rat, and mouse. Dog plasma contained only traces of 2-pyrrolidinone not exceeding significantly the detection limit of our GCMS-method. Succinimide but not 2-pyrrolidinone could also be found in the brains of rat and mouse. Evidence is presented for a metabolic pathway leading from 2-pyrrolidinone to succinimide, with 5-hydroxy-2-pyrrolidinone as an intermediate.
Databáze: MEDLINE