Creatine kinase isoenzymes in serum from children--especially focusing on CK-BB.

Autor: Jørgensen FB, Badskjaer J, Pedersen BS, Boysen K
Jazyk: angličtina
Zdroj: Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 1984 Sep; Vol. 44 (5), pp. 429-32.
DOI: 10.3109/00365518409083833
Abstrakt: In 161 children with ages ranging from 7 months to 18 years the concentration of CK-BB in serum was measurable in 58%. The activity in serum of CK-BB (cCK-BB(S] in children varies with age and is not significantly influenced by seizure, epilepsy or body temperature. The values are most elevated during the first year of life and show a rapid fall, never reaching adult levels. Comparing mean cCK-BB(S) values in children to growth charts the resemblance is striking. CK-BB is the only CK-isoenzyme that changes with age. We postulate that cCK-BB(S) is related to growth as a physiological phenomenon. CK-MB was found in serum in 7% of the children and could not be of cardiac origin. Therefore CK-MB cannot be regarded as cardiac specific in children.
Databáze: MEDLINE