| Autor: |
Edwards MS, Gordon DG, Salamy A, Levin VA, Phillips TL |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neuro-oncology [J Neurooncol] 1984; Vol. 2 (2), pp. 95-8. |
| Abstrakt: |
Rats pretreated for 5 days with 50 mg/kg of pentobarbital tolerated statistically significant higher doses of misonidazole before the onset of misonidazole-induced neurotoxicity than rats treated intermittently with the same dose of pentobarbital. Presumably in pretreated rats, pentobarbital induced an increase in the activities of hepatic microsomal enzymes that led to a more rapid metabolism of misonidazole than in rats treated only intermittently. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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