| Autor: |
Mills EH, Coghlan JP, Denton DA, Spence CD, Whitworth JA, Scoggins BA |
| Jazyk: |
angličtina |
| Zdroj: |
Acta endocrinologica [Acta Endocrinol (Copenh)] 1984 Aug; Vol. 106 (4), pp. 521-6. |
| DOI: |
10.1530/acta.0.1060521 |
| Abstrakt: |
This study examines the physiological effects of 11-deoxycorticosterone (DOC) at 2 rates of continuous iv infusion for 5 days in conscious sheep. DOC treatment, in sheep on Na and K intake 80 and 120 mmol/day respectively, increased mean arterial pressure (MAP) by 12 mmHg at 50 mg/day and by 10 mmHg at 5 mg/day. Both rates of infusion raised plasma [Na] and lowered plasma [K]. Urinary Na excretion fell on the first day of infusion. On cessation of infusion there was a natriuresis. A high K intake of approximately 800 mmol/day for 7 to 10 days prior to and during DOC (5 mg/day) treatment abolished the rise in blood pressure, the rise in plasma [Na], the initial Na retention and the post-DOC natriuresis. Plasma [K] rose with high K intake and fell with DOC. Na depletion prior to DOC infusion (5 mg/day) prevented the rise in MAP. Urinary Na excretion remained low and plasma [K] fell. This study shows that K loading abolishes DOC hypertension in sheep by a mechanism which may involve modification of the Na retaining effects of the steroid. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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