Activity of Carbetimer in a human tumor cloning system.

Autor: Kisner DL, Mehta P, Paget GE, Von Hoff DD
Jazyk: angličtina
Zdroj: Investigational new drugs [Invest New Drugs] 1984; Vol. 2 (1), pp. 55-8.
DOI: 10.1007/BF00173787
Abstrakt: The antitumor activity of Carbetimer was tested against 171 patient's tumors in a human tumor cloning system. Sixty-seven tumor specimens had adequate growth to be considered evaluable. In 21 specimens survival of tumor colony forming units was less than or equal to 50% that in control plates. Antitumor effect was most impressive in carcinomas of the breast, ovary, and lung. This information will be useful in planning disease oriented Phase II trials.
Databáze: MEDLINE