| Autor: |
Polikarpova LI, Teriukova NP, Kalashnikova NM, Oleĭnik IA, Klimov AN |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy meditsinskoi khimii [Vopr Med Khim] 1984; Vol. 30 (6), pp. 98-101. |
| Abstrakt: |
Native HDL, HDL2 or HDL3, isolated from donor plasma were intravenously administered at a large dose (100 mg HDL cholesterol) to healthy rabbits and rabbits with experimental hypercholesterolemia. The elimination rate of human HDL was studied on the basis of alpha-cholesterol (alpha-Ch) and apoprotein (apo) A-I determinations in the plasma of rabbits. Administration of HDL or their subclasses at a large dose with the following determination of alpha-Ch or apo A-I enabled to avoid the use of radioactive label and all the methodological errors connected with the latter. After administration of HDL, HDL2 and HDL3 their elimination according to alpha-Ch determination occurred at the higher rate as compared with apo A-I. Elimination of the total HDL fraction according to alpha-Ch determination was higher in healthy rabbits than in animals with hypercholesterolemia while the elimination estimated by the apo A-I determination was similar in both groups of animals. These data suggest that HDL may characterize the Ch-donor properties. Apo A-I as compared with alpha-Ch was a more accurate indicator of HDL concentration in blood plasma. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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