| Autor: |
Quitkin FM, Liebowitz MR, Stewart JW, McGrath PJ, Harrison W, Rabkin JG, Markowitz J, Davies SO |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of general psychiatry [Arch Gen Psychiatry] 1984 Aug; Vol. 41 (8), pp. 777-81. |
| DOI: |
10.1001/archpsyc.1984.01790190051006 |
| Abstrakt: |
We investigated the antidepressant efficacy of l-deprenyl (selegiline), a selective monoamine oxidase B inhibitor (MAOI), in a six-week open trial of 17 patients with atypical depression. Such patients have previously been shown to benefit from nonselective MAOIs such as phenelzine sulfate. Ten patients (59%) responded to l-deprenyl, but nine required dosages above the 10 to 20 mg/day used in previous investigations. l-Deprenyl was superior to six weeks of placebo administered to diagnostically similar patients in a separate double-blind study. In contrast with previous findings with pheneizine, responders to l-deprenyl differed from nonresponders by having lower baseline anxiety ratings. Even at high dosages, there appeared to be fewer side effects with l-deprenyl than with nonselective MAOIs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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