A functional cyclooxygenase enzyme is not required for mediation of the pleiotropic effects of human alpha or beta interferon.

Autor: Forti RL, Mitchell WM, Workman RJ, Forbes JT, Hubbard WC
Jazyk: angličtina
Zdroj: Prostaglandins [Prostaglandins] 1983 Sep; Vol. 26 (3), pp. 409-20.
DOI: 10.1016/0090-6980(83)90176-4
Abstrakt: Aspirin, indomethacin, and phenbutazone at 50 microM concentration inhibit cyclooxygenase in cultured human foreskin fibroblasts as evidenced by the suppression of the major prostaglandin species which accumulate in the culture medium. In contrast to data reported for mouse interferon on target mouse cells, these agents have no effect on the induction of antiviral activity by human alpha or beta interferons. Similarly, these agents have no effect on interferon induced inhibition of cell growth in vitro or on interferon induced natural killer cell activity.
Databáze: MEDLINE