| Autor: |
Sukhorukov VL, Potanenko AIa, Zakharova VA |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy meditsinskoi khimii [Vopr Med Khim] 1983 Sep-Oct; Vol. 29 (5), pp. 75-8. |
| Abstrakt: |
Well-known skin photosensitizers furocoumarins--psoralen, angelio in and 8-methoxypsoralen were shown to photosensitize oxidation of unsaturated lipids and dihydroxyphenylalanine via a two-step mechanism. At the first step (UV-irradiation at 366 nm) photooxidation of furocoumarins occurred, at the second step--the photooxidized furocoumarins oxidized unsaturated lipids or dihydroxyphenylalanine in darkness. The photochemical activity of furocoumarins in the two-step reaction decreased as follows: psoralen greater than angelicin greater than 8-methoxypsoralen. Similar photoreactions appear to participate in induction of phototoxic effects of furocoumarins. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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