| Autor: |
Andreana A, Dilillo MA, Perna P, Ruggiero G |
| Jazyk: |
italština |
| Zdroj: |
Bollettino della Societa italiana di biologia sperimentale [Boll Soc Ital Biol Sper] 1984 Jun 30; Vol. 60 (6), pp. 1229-31. |
| Abstrakt: |
Using isolated and perfused rat livers we found an inhibitory effect on intracellular killing of hepatic macrophages versus E. coli, in presence of therapeutic levels of amphotericin B (5 micrograms/ml). Since an interference of this antibiotic with phagocytic functions of human neutrophils has also been reported, we suggest that amphotericin B may exert a toxic effect on intraphagocytic microbicidal function, possibly by an interaction with membrane sterols. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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