| Autor: |
Harrist TJ, Bhan AK, Murphy GF, Sato S, Berman RS, Gellis SE, Freedman S, Mihm MC Jr |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of clinical pathology [Am J Clin Pathol] 1983 Mar; Vol. 79 (3), pp. 294-300. |
| DOI: |
10.1093/ajcp/79.3.294 |
| Abstrakt: |
Cutaneous lesions in three cases of histiocytosis-X were studied by light microscopy, electron microscopy, and immunoperoxidase technics. In each case, Birbeck granule-containing histiocytosis-X cells infiltrated the epidermis and were apposed to lymphocytes. The histiocytosis-X cells and normal Langerhans cells stained with anti-T6 and anti-I1 (Ia-like) antibodies but were negative with anti-T3, anti-T8, anti-M1, and anti-lysozyme antibodies. In addition, the histiocytosis-X cells also stained with anti-T4 antibodies, which react with T-cells associated with helper/inducer phenotype. This study supports the hypothesis that histiocytosis-X cells are abnormal Langerhans cells. The presence of T4/T6-positive cells in cutaneous disease may be a marker for abnormal Langerhans cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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