| Autor: |
Samson MK, Baker LH, Devos JM, Buroker TR, Izbicki RM, Vaitkevicius VK |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer treatment reports [Cancer Treat Rep] 1976 Jan; Vol. 60 (1), pp. 91-7. |
| Abstrakt: |
Seventeen patients with various histologic types of incurable malignant disease were treated with a combination of vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II). Creatinine and blood urea nitrogen elevations were noted but were not of a severe degree. White blood cell and platelet count depressions were seen and appeared to be cumulative, though not life-threatening. Tinnitus and high-frequency hearing loss were noted. Tumor regression was seen in one patient with adenocarcinoma of the lung and in one patient with a testicular tumor. This appears to be a manageable drug combination with frequent monitoring of renal, hematopoietic, pulmonary, and auditory function. A phase II study establishing the therapeutic efficacy of this combination in advanced testicular neoplasms now appears to be indicated. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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