| Autor: |
Posner P, Peterson CV, Pitha J, Baker SP |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of pharmacology [Eur J Pharmacol] 1984 May 04; Vol. 100 (3-4), pp. 373-6. |
| DOI: |
10.1016/0014-2999(84)90016-5 |
| Abstrakt: |
In isolated rat atria, 1 microM bromoacetylalprenololmentane shifted the tension development curve for isoproterenol to the right of the control curve. After a 2 h washout period, no significant recovery of the isoproterenol concentration-response curve had occurred. Pretreatment of rat atrial membranes with 1 microM bromoacetylalprenololmentane resulted in an 83% decrease in the concentration of beta-adrenoceptors with no change in the KD value for [125I]iodocyanopindolol binding to the receptors left. The results indicated that bromoacetylalprenololmentane was an irreversible beta-blocker. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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