| Autor: |
Made Gowda NM, Smith LL |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of steroid biochemistry [J Steroid Biochem] 1984 Apr; Vol. 20 (4A), pp. 917-22. |
| DOI: |
10.1016/0022-4731(84)90406-0 |
| Abstrakt: |
Reduction of sterol hydroperoxides 3 beta-hydroxy-5 alpha-cholest-6-ene-5-hydroperoxide and cholesterol 7 alpha-hydroperoxide by KO2 (or other strong base in air) solubilized by crown ether in dimethylsulfoxide gave only corresponding alcohols, but in the presence of cholesterol (or other sterols) gave 3 beta-hydroxycholest-5-en-7-one together with the corresponding alcohols. Both hydroperoxides likewise gave the corresponding alcohol and ketone products with KO2 in benzene and in oxidations by ceric ammonium nitrate in a biphasic system. The 7-ketone product is recognized as deriving from termination reactions of sterol peroxyl and/or oxyl radicals. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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