| Autor: |
Parsons WH, Davidson JL, Taub D, Aster SD, Thorsett ED, Patchett AA, Ulm EH, Lamont BI |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1983 Nov 30; Vol. 117 (1), pp. 108-13. |
| DOI: |
10.1016/0006-291x(83)91547-4 |
| Abstrakt: |
A series of potent inhibitors of angiotensin-converting enzyme (dipeptidyl carboxypeptidase, E.C. 3.4.15.1) derived from benzofused 1-carboxyalkyl-3-(1-carboxy-3-phenyl-propylamino) lactams (III) is described. In the most effective inhibitors (I50 2-4 X 10(-9)M) the lactam is 7 or 8 membered and the N-1 side chain is carboxymethyl or carboxyethyl. Conformational and steric factors pertinent to binding to the enzyme are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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