The effect of hexadimethrine bromide (polybrene) on the infection of the primate retroviruses SSV 1/SSAV 1 and BaEV.
| Autor: | Coelen RJ, Jose DG, May JT |
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| Jazyk: | angličtina |
| Zdroj: | Archives of virology [Arch Virol] 1983; Vol. 75 (4), pp. 307-11. |
| DOI: | 10.1007/BF01314897 |
| Abstrakt: | Polybrene was shown to enhance the adsorption of simian sarcoma virus-simian sarcoma associated virus complex (SSV-1/SSAV-1) and baboon endogenous virus (BaEV) onto cells in culture. A 16- to 18-fold increased adsorption of both viruses occurred at 8 micrograms/ml polybrene within one hour after infection. The polybrene mediated adsorption was found to be inhibited by the addition of tri-sodium citrate to the culture medium, suggesting the involvement of electrostatic forces. This contention was further supported by the demonstration of temperature independence of the polybrene mediated interaction. |
| Databáze: | MEDLINE |
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