Detection of anti-varicella-zoster virus antibodies in blood donors by automated passive haemagglutination.

Autor: Chung A, Naylor DH
Jazyk: angličtina
Zdroj: Vox sanguinis [Vox Sang] 1981; Vol. 41 (4), pp. 245-8.
DOI: 10.1111/j.1423-0410.1981.tb01044.x
Abstrakt: 1,219 normal blood donors were screened for anti-varicella-zoster virus antibodies by automated passive haemagglutination (APH) on a Technicon 15-channel AutoAnalyzer. 98 samples (8%) were positive by APH and 92% of these were shown to have antibody titres greater than or equal to 1/16 by indirect immunofluorescence assay (IFA). Parallel testing on an additional 265 donors revealed that 11 (4%) individuals had IFA titres greater than 1/16 and 6 of these 11 donors were identified by APH. Thus, APH is an effective means of rapidly detecting units of plasma acceptable for production of varicella-zoster immunoglobulin.
Databáze: MEDLINE