| Autor: |
Robertson HA, Baker GB, Coutts RT, Benderly A, Locock RA, Martin IL |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of pharmacology [Eur J Pharmacol] 1981 Dec 03; Vol. 76 (2-3), pp. 281-4. |
| DOI: |
10.1016/0014-2999(81)90515-x |
| Abstrakt: |
The effects of a number of beta-carboline derivatives on [3H]flunitrazepam binding to the benzodiazepine binding site were investigated. The potency of beta-carbolines at the benzodiazepine binding site appeared to be determined largely by the aromaticity of the molecule. Norharmane-3-carboxylic acid ethyl ester was considerably more potent (IC50 10 nM) than its tetrahydro-beta-carboline analogue (IC50 6 microM). There is essentially no difference in potency between the (+)- and (--)-forms of the tetrahydro-beta-carboline-3-carboxylate analogues. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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