| Autor: |
Kudriavtseva NV, Vinogradova NA, Novikov IP, Nikol'skiĭ NN |
| Jazyk: |
ruština |
| Zdroj: |
Tsitologiia [Tsitologiia] 1981 Dec; Vol. 23 (12), pp. 1403-10. |
| Abstrakt: |
The role of cyclic GMP in the insulin effect was investigated using isolated frog sartorii. A study was made of the effect of exogenous cyclic GMP, dibutyryl cyclic GMP, 8-bromo-cyclic GMP on xylose transport, glycogen synthesis and muscle respiration. Only dibutyryl cyclic GMP (1.10(-6) - 10(-4) M) alone was observed to have a stimulating effect on glycogen synthesis and respiration. The xylose transport was but slightly accelerated only following a 20 hours incubation of muscles in the cyclic GMP solution. Cyclic GMP was shown to penetrate the muscle fibres. The cyclic GMP content in muscles was equal to 22.7 +/- 2.0 pM per gram of wet weight. Insulin exerted no effect on cyclic GMP concentration in muscles. The data obtained do not allow to conclude that cyclic GMP may serve as a mediator in realization of the insulin effect on membrane and intracellular processes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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