GABA receptors distribution in rat substantia nigra.

Autor: De Montis GM, Olianas MC, Mulas G, Lloyd KG, Tagliamonte A
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 1981 May 29; Vol. 23 (3), pp. 257-61.
DOI: 10.1016/0304-3940(81)90007-0
Abstrakt: The perikarya of the dopaminergic and non-dopaminergic neurons contained in the substantia nigra were selectively destroyed by a proper, local injection of 6-hydroxydopamine or kainic acid, respectively. Both lesions resulted in a marked decrease of the nigral GABA-binding sites. The effect of 6-hydroxydopamine was restricted to the high affinity receptors, while kainic acid specifically decreased the low affinity ones.
Databáze: MEDLINE