| Autor: |
Lunevskiĭ VZ, Zherelova OM, Aleksandrov AA, Vinokurov MG, Berestovskiĭ GN |
| Jazyk: |
ruština |
| Zdroj: |
Biofizika [Biofizika] 1980 Jul-Aug; Vol. 25 (4), pp. 685-91. |
| Abstrakt: |
The present work was intended to further investigate the selective filter of calcium channel on both a cell membrane and reconstructed channels. For the studies on cell membranes, an inhibitor of chloride channels was chosen (ethacrynic acid) to pass currents only through the calcium channels. On both the cells and reconstructed channels, permeability of ions of different crystal radii and valencies was investigated. The obtained results suggest that the channel represents a wide water pore with a diameter larger than 8 A into which ions go together with the nearest water shell. The values of the maximal currents are given by electrostatic interaction of the ions with the anion center of the channel. A phenomenological two-barrier model of the channel is given which describes the movement of all the ions studied. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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