Serum antibodies to herpes simplex virus type 1 during active oral herpes infection.
| Autor: | Ratner JJ, Smith KO |
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| Jazyk: | angličtina |
| Zdroj: | Infection and immunity [Infect Immun] 1980 Jan; Vol. 27 (1), pp. 113-7. |
| DOI: | 10.1128/iai.27.1.113-117.1980 |
| Abstrakt: | Subjects with oral herpes lesions at the time of serum sampling had higher-efficiency antibody (higher proportion of neutralizing antibody as determined by plaque reduction, compared with total antibody as detected by radioimmunoassay) to herpes simplex virus type 1 (HSV-1) than did subjects with no lesions at the time of serum sampling. These higher-efficiency sera also had higher antibody titers to structural components of herpes simplex virus type 1 than did the low-efficiency sera. Absorption of high- and low-efficiency sera with purified herpes simplex virus type 1 particles removed all neutralizing antibody but not all antibody detected by radioimmunoassay. High-efficiency serum was depleted of more antibody to particulate antigen that was the low-efficiency serum, indicating that the high-efficiency serum contained a higher proportion of antibody to the virus particle. |
| Databáze: | MEDLINE |
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