| Autor: |
Linch DC, Knott LJ, Thomas RM, Harper P, Goldstone AH, Davis EG, Levinski RJ |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of haematology [Br J Haematol] 1983 Mar; Vol. 53 (3), pp. 451-8. |
| DOI: |
10.1111/j.1365-2141.1983.tb02046.x |
| Abstrakt: |
Venous blood T cell phenotypes were analysed with monoclonal antibodies after 11 allogeneic and 17 autologous bone marrow transplants. In seven cases studied in the early regenerative period, cells with a thymocyte phenotype were present in the blood. In the large majority of patients treated with both allografts and autografts there was an imbalance of phenotypic 'helper' and 'suppressor' T cell subsets with initially a relative and later an absolute increase of 'suppressor' T cells. This imbalance was still present at over 250 d in eight out nine cases. Suppressor T cells bearing HLA-Dr antigens were abundant in one case of fatal GVHD but not in another, and were also increased following two autografts. It is concluded that T cell phenotyping is not of diagnostic value in sick patients following bone marrow transplantation when graft-versus-host disease is suspected. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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