| Autor: |
Huang L, Rowin G, Dunn J, Sykes R, Dobna R, Mayles BA, Gross DM, Burg RW |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 1984 May; Vol. 37 (5), pp. 462-5. |
| DOI: |
10.7164/antibiotics.37.462 |
| Abstrakt: |
L-681,176, an inhibitor of angiotensin converting enzyme was found in the culture filtrate of Streptomyces sp. MA 5143. The I50 of the crystalline inhibitor is about 1.3 micrograms/ml and the inhibition is reversed by zinc sulfate. In rats, L-681,176 exhibits a dose-related inhibition of the pressor response to angiotensin I with an ID50 of 142 mg/kg when administered intravenously. The structure of L-681,176 is similar to that of marasmine but lacking one carboxyl group. The maximum yield of L-681,176 occurs after three to four days growth at 28 degrees C. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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