| Autor: |
Zukin SR, Brady KT, Slifer BL, Balster RL |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research [Brain Res] 1984 Feb 27; Vol. 294 (1), pp. 174-7. |
| DOI: |
10.1016/0006-8993(84)91326-x |
| Abstrakt: |
The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at mu opiate and sigma opiate/phencyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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